To what extent and on what timescales do the structures of proteins change in the gas phase? We used time-dependent IM-IM-MS and collision-induced unfolding to find out. Congratulations to Ben Zercher, Cece Hong, Addison Roush, and Bruce Feng, whose paper was just published in Analytical Chemistry.
This article was selected for ACS Editors’ Choice, which is a collection designed to feature scientific articles of broad public interest that are made free to readers. One selection is made per day, across all 75+ ACS journals.
Are the Gas-Phase Structures of Molecular Elephants Enduring or Ephemeral? Results from Time-Dependent, Tandem Ion Mobility. Benjamin P. Zercher, Seoyeon Hong, Addison E. Roush, Yuan Feng, Matthew F. Bush. Anal. Chem. 2023, 95, 9589–9597. (Link)