About the Bush Lab

The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.

Recent News

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Lindsey Ulmer successfully defended her dissertation!

Congratulations to Dr. Lindsey Ulmer, who successfully defended her thesis titled “New Photo-Crosslinking Mass Spectrometry Approaches for the Study of Intrinsically Disordered Proteins.” Lindsey has accepted an offer to join Waters Corporation as Senior Scientist for the Evaluations group in the Cell and Gene Consumables team. We all wish Lindsey great success and happiness in …

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New Publication: High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid

Congratulations to Lindsey Ulmer, whose research was just published in the Journal of Proteome Research! This research demonstrates significant advances in identifying residue-specific crosslinks originating from a photoreactive amino acid, which we have been using to characterize proteins with intrinsic disorder. High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid. Lindsey …

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May Constabel successfully defended her dissertation!

Congratulations to May Constabel, who successfully defended her thesis titled “Programmed Temperature Electrospray Ionization (ptESI) for Thermal Cycling of Proteins”. May will soon complete her degree in the M.S. in Applied Chemical Science and Technology (MSACST) program. May has accepted an offer to join the laboratory of Prof. Anouk Rijs at the Vrije Universiteit Amsterdam …

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Research

Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.