About the Bush Lab

The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.

Recent News

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New Publication: SLIMPHONY: A SLIM-Based Instrument That Orchestrates Complex Ion Mobility–Mass Spectrometry Experiments

Congratulations to AnneClaire Wageman, Addison Roush, and Bruce Feng! SLIMPHONY is a new instrument that we built using the Structures for Lossless Ion Manipulations (SLIM) architecture. SLIMPHONY is unique in that eight independently controlled traveling-wave regions work in concert to enable complex, multidimensional separations. With the ability to select and activate ions in multiple regions, …

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Cascadia Proteomics and Congratulations to Lucas Narisawa!

Another great Cascadia Proteomics for the Bush Lab, including a talk Addison Roush and poster+lightning talks by Anna Lin, Lucas Narisawa, and Chris Weir. We also enjoyed presentations by lab alumni Theresa Gozzo and Evan Hubbard, who now work for Just-Evotec and Talus Biosystems, respectively, as well as so many collaborators and friend. Finally, we …

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Lindsey Ulmer successfully defended her dissertation!

Congratulations to Dr. Lindsey Ulmer, who successfully defended her thesis titled “New Photo-Crosslinking Mass Spectrometry Approaches for the Study of Intrinsically Disordered Proteins.” Lindsey has accepted an offer to join Waters Corporation as Senior Scientist for the Evaluations group in the Cell and Gene Consumables team. We all wish Lindsey great success and happiness in …

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Research

Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.