Matt Bush

May. 2018May. 2018

Bush Lab at ASMS 2018

Members of the Bush Lab will present the following talks at American Society for Mass Spectrometry Annual Conference in San Diego (June 3 – 7, 2018):

Ion Mobility of Proteins in Nitrogen Gas: Effects of Charge State, Charge Distribution, and Structure Characterized using Trajectory Method Calculations. Daniele Canzani; Matthew F, Bush. (MP 407)
Collision-Induced Unfolding and Dissociation Reveal the Location of Ni(II) Binding in the Dimer of the Alpha-Crystallin Domain of HSPB5. Seoyeon Hong; Matthew F. Bush. (MP 745)
Memory of the Condensed-Phase in the Gas-Phase: Effects of Solution, Charge, and Energy on Structures of Serum Albumin Ions. Meagan Gadzuk-Shea; Matthew F Bush. (WOB 10:10)

We look forward to seeing everyone in San Diego!

May. 2018

Congratulations to Julia Greenwald, recipient of the Bruce Kowalski Award!

Congratulations to Julia Greenwald, who received the Bruce R. Kowalski Award for Multidisciplinary Research. The award is given to the best lightning talk at the Center for Process Analysis and Control annual meeting.

Mar. 2018Jun. 2018

Rae Eaton is named an ACS Division of Analytical Chemistry Graduate Fellow!

Congratulations to Rae Eaton, who just received a Graduate Fellowship from the American Chemical Society Division of Analytical Chemistry! This award is sponsored by Agilent Technologies.

Mar. 2018Mar. 2018

New Publication: Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas

Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas: improving the accuracy of trajectory method calculations. Jong Wha Lee, Hyun Hee L. Lee, Kimberly L. Davidson, Matthew F. Bush, Hugh I. Kim. Analyst 2018, in press. (Link)

The investigation of ion structures based on a combination of ion mobility mass spectrometry (IM-MS) experiments and theoretical collision cross section (CCS) calculations has become important to many fields of research. However, the accuracy of current CCS calculations for ions in nitrogen drift gas limits the information content of many experiments. In particular, few studies have evaluated and attempted to improve the theoretical tools for CCS calculation in nitrogen drift gas. In this study, Continue reading “New Publication: Structural characterization of small molecular ions by ion mobility mass spectrometry in nitrogen drift gas”

Nov. 2017

Research in the Bush Lab Featured in the ACS PRF Annual Report

Our research on “Fundamental Interactions Between Petroleum Ions and Gases” was featured in the most recent annual report from the American Chemical Society Petroleum Research Fund. Congratulations to Kim Davidson and Anna Bakhtina!

Oct. 2017

New Publication: Collision Cross Sections and Ion Structures

Collision Cross Sections and Ion Structures: Development of a General Calculation Method via High-quality Ion Mobility Measurements and Theoretical Modeling. Jong Wha Lee, Kimberly L. Davidson, Matthew F. Bush, Hugh I. Kim. Analyst 2017, in press. (Link)

Ion mobility mass spectrometry (IM-MS) has become an important tool for the structural investigation of ions in the gas phase. Accurate theoretical evaluation of ion collision cross sections (CCSs) is essential for the effective application of IM-MS in structural studies. However, current theoretical tools have limitations in accurately describing a broad range of ions from small molecules to macromolecules. Continue reading “New Publication: Collision Cross Sections and Ion Structures”

Oct. 2017Oct. 2017

International Journal of Mass Spectrometry Cover

Congratulations to Kim Davidson, whose research is featured on the cover of the special issue on “New developments and applications of mass spectrometry methods for studying non-covalent protein interactions”.

Nonspecific Aggregation in Native Electrokinetic Nanoelectrospray Ionization. Kimberly L. Davidson; Derek R. Oberreit; Christopher J. Hogan; Matthew F. Bush. Int. J. Mass Spectrom. 2017, 420, 35–42. (Link | Cover)

Sep. 2017

New Publication: Effects of Charge State, Charge Distribution, and Structure on the Ion Mobility of Protein Ions in Helium Gas

Effects of Charge State, Charge Distribution, and Structure on the Ion Mobility of Protein Ions in Helium Gas: Results from Trajectory Method Calculations. Kenneth J. Laszlo, Matthew F. Bush. J. Phys. Chem. A, 2017, in press. (Link)

Collision cross section (Ω) values of gas-phase ions of proteins and protein complexes are used to probe the structures of the corresponding species in solution. Ions of many proteins exhibit increasing Ω-values with increasing charge state but most Ω-values calculated for protein ions have used simple collision models that do not explicitly account for charge. Here we use a combination of ion mobility mass spectrometry experiments with helium gas and trajectory method calculations to characterize the extents to which increases in experimental Ω-values with increasing charge state may be attributed to increased momentum transfer concomitant with enhanced long-range interactions between the protein ion and helium atoms. Continue reading “New Publication: Effects of Charge State, Charge Distribution, and Structure on the Ion Mobility of Protein Ions in Helium Gas”

Aug. 2017

ACS Fall National Meeting in DC 2017

Matt Bush presented the following talks at the ACS Fall National Meeting in Washington DC, where he also received the Arthur F. Findeis Award for Achievements by a Young Analytical Scientist.

ANYL 269: Interpreting the collision cross sections of proteins: Insights from ion mobility, unfolding, and folding of ions in the gas phase, as a part of the Analytical Division Award Symposium.

PHYS 322: Effects of charge state on the structures of protein ions: Results from cation-to-anion proton-transfer reactions (CAPTR), as a part of the symposium on Gaseous Ion Chemistry & Surface Reactions.