Bio
Addison Roush graduated from the University of Mississippi with a B.S. in chemistry and a minor in mathematics in 2020. During his time there, he published work on an optical method for hydroxyl radical dosimetry for use with the Fast Photochemical Oxidation of Proteins (FPOP) technique, and he completed an honors thesis on the subject with his advisor Dr. Joshua S. Sharp. In 2019, he also participated in an NSF-REU at the University of California, San Francisco where he investigated the interaction between the Alzheimer’s Disease associated proteins TREM-2 and amyloid beta by crosslinking mass spectrometry. This work was completed under the direction of Drs. Haifan Wu and William F. DeGrado and was published in 2022. He joined the Bush lab in the winter of 2020, and he is currently involved in the structures for lossless ion manipulations (SLIM) project.
Publications
Ketaki D. Belsare, Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin, Hyunil Jo, Addison E. Roush, Kala Bharath Pilla, Andrej Sali, Carlo Condello, William F. DeGrado. “Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.” PNAS, 2022, 119 (5) e2114486119. https://doi.org/10.1073/pnas.2114486119
Addison E. Roush, Mohammad Riaz, Sandeep K. Misra, Scot R. Weinberger, and Joshua S. Sharp. “Intrinsic Buffer Hydroxyl Radical Dosimetry Using Tris(hydroxymethyl)aminomethane.” Journal of the American Society for Mass Spectrometry, 2019, 31 (2), 169-172. https://doi.org/10.1021/jasms.9b00088
Awards
National Science Foundation-Graduate Research Fellowship, 2022
Goldwater Scholarship, 2019