Native mass spectrometry studies often report initial pH, but is that the pH of samples during experiments? Using ratiometric fluorescence imaging, we find that sample pH can drift during experiments. Congratulations to Meagan Gadzuk-Shea, Evan Hubbard, and Theresa Gozzo, whose paper was just published in the Journal of the American Society for Mass Spectrometry!
Sample pH Can Drift during Native Mass Spectrometry Experiments: Results from Ratiometric Fluorescence Imaging. Meagan M. Gadzuk-Shea, Evan E. Hubbard, Theresa A. Gozzo, Matthew F. Bush. J. Am. Soc. Mass Spectrom. 2023, 34, 1675–1684. (Link)